Vitamin D3

Protect your overall health.

Vitamin D3 is the only vitamin our bodies can make with sun exposure, using the energy of UVB rays to convert 7-dehydrocholesterol into vitamin D3. (To note, one widely held opinion is that D3 is technically not a vitamin but a hormone). Without sufficient sun exposure, individuals may therefore become deficient in this valuable nutrient; it is estimated that one billon people worldwide have a deficiency or insufficiency, and up to half of U.S. adults and 30 percent of children and teenagers have a vitamin D deficiency.

Currently, there are many reasons for decreased sun exposure, from living in sun-starved latitudes to wearing various forms of sun protection that protect against skin cancer. Additionally, most Americans do not eat enough dietary sources of vitamin D (e.g. cod liver, sardines, fish) to get a healthy dose of it, and fortified foods like milk and cereal simply do not provide enough of it. Furthermore, as we age, we are less equipped to produce sufficient quantities of this vital nutrient. Therefore, Vitamin D supplementation seems to be the best option for many individuals to receive the amount their bodies need.

Pure Essentials Ultra Vitamin D3 provides a safe, natural form of the nutrient in liquid with medium chain triglycerides (MCT) for the most effective uptake and absorption. Additional protection is provided by mixed natural tocopherols and ascorbyl palmitate in a natural rosemary extract.

Pure Essentials Ultra Vitamin D3 serves important functions in your body that, together, support your overall health:

·       Bone Health

 Vitamin D3 sufficiency is essential for maximizing bone health, as it enhances intestinal absorption of calcium and phosphorus. Conversely, a deficiency can cause bone weakness (in the form of osteopenia, osteoporosis or osteomalacia), as well as muscle weakness, both of which increase the risk of bone falls and fractures. Fortunately, vitamin D3 supplementation can prevent and help correct these conditions.

• Immune Health
  
  Most organs and immune cells have a vitamin D receptor, and some also have the capacity to metabolize 25-hydroxyvitamin D to the active form of vitamin D: 1,25-dihydroxyvitamin D. 1,25-dihydroxyvitamin D is a potent immunomodulator that blunts generalized over-proliferation of both lymphocytes and monocytes while sharpening the immune system's attack on specific targets. It also inhibits the development of autoimmune diseases like multiple sclerosis and irritable bowel syndrome and enhances the production and secretion of several hormones, including insulin.
  
  
• Diabetes and Heart Health
  
  Vitamin D affects hormone levels, including insulin. A vitamin deficiency can thereby increase the risk of diabetes, which is a major contributor to cardiovascular disease. Furthermore, low vitamin D levels (especially below 30 ng/ml) can activate the renin-angiostensin-aldosterone system, which may lead to hypertension as well as stiffening of the heart and blood vessels. As a result, when a vitamin D deficiency is corrected, glycemic control and insulin resistance are improved, as is cardiovascular health.
  
  
• Cognitive Health
  
  Short-term and smaller clinical studies have indicated that serum 25-hydroxyvitamin D (25(OH)D) concentration may be associated with dementia and cognitive function. Recent results from a large clinical study involving 1,766 adults aged 65 years and older show that those with normal cognitive function had higher levels of serum Vitamin D3 than those who were cognitively impaired, further strengthening the neuroprotective role of vitamin D3. Research also indicates that vitamin D levels can predict risk of fatal stroke, and supplementation could even prevent stroke. Risk of stroke usually increases with age, and since very low vitamin D levels are common in the elderly, this connection is important, especially as supplementation may be used to maintain health and prevent disease.
  
  
• Overall Protection
  
  Vitamin D deficiency is associated with obesity, hypertension, glucose intolerance, and metabolic syndrome (insulin resistance). It has also been associated with other chronic illnesses including fibromyalgia, fatigue, colon and prostate conditions, autoimmune disorders, chronic inflammation, and polycystic ovarian disease. Research into its connection with other conditions is ongoing. In essence, vitamin D3 provides valuable and complete health support.
  

Typical Dosage

Researchers currently believe that the 400IU/day required to prevent rickets and osteomalacia is not enough. For health maintenance and disease prevention, doses of 400-1000 IU/day for children and 2000-5000 IU/day are being accepted as more realistic. Of note, the biochemical parameter used to gauge the vitamin D status of an individual is the blood concentration of 25(OH)D, which is the circulating vitamin D metabolite known as calcidiol. Healthy blood levels of this metabolite range between 50-80 ng/ml (versus a deficiency, which is defined as <20ng/ml). Of the various forms of vitamin D available, vitamin D3 is most effective in increasing the blood levels of 25(OH)D.

Pure Essentials Ultra Vitamin D3 is available in bottles of 30 ml. As a dietary supplement, take one (1) drop per day, or as directed by your health professional. It may be administered directly on to spoon or a piece of toast.

One (1) Pure Essentials Ultra Vitamin D3 drop provides:

Energized Nutrients
Pure Vitamin D3 (cholecalciferol) 500 IU
Medium Chain Triglycerides (MCT) 87 mg
Vitamins E (from mixed natural tocopherols) † 20 IU
Ascorbyl palmitate 2 mg

Other ingredients: Rosemary essence oil, organic sunflower oil.

† Vitamins E is stated to reinforce the fact that Pure Essentials uses the alpha, beta, gamma, and delta forms of the natural tocopherols.

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References

Cantorna MT, et al. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr. 2004;80(6):1717S-1720S.

Holick MF. Diabetes and the vitamin D connection. Curr Diab Rep. 2008;8(5):393-8.

Holick MF. Optimal vitamin D status for the prevention and treatment of osteoporosis. Drugs Aging. 2007;24(12):1017-29.

Llewellyn DJ, et al. Serum 25-Hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol. 2009;22(3):188-95.

Massey, Peter. “Vitamin D supplements may stave off a stroke.” Daily Herald. 2008 Nov 3. http://prev.dailyherald.com/story/?id=247678. Accessed 8 Sept. 2016.

Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: A systematic review and meta-analysis. Archives of Disease in Childhood. 2008;93(6):512-7.