Replenish your joints.
According to the American College of Rheumatology, as of 2016 our nation’s joints are in painful disrepair: “The lifetime risk of developing [osteoarthritis (OA)] of the knee is about 46 percent, and the lifetime risk of developing OA of the hip is 25 percent, according to the Johnston County Osteoarthritis Project, a long-term study from the University of North Carolina and sponsored by the Centers for Disease Control and Prevention (often called the CDC) and the National Institutes of Health.”
To combat discomfort, non-steroidal anti-inflammatory drugs (NSAIDS) are typically used due to their inhibition of pain signals. However, these drugs can also inhibit the synthesis of cartilage building blocks, which ultimately promotes cartilage loss. And they can result in well-documented side effects such as abnormal liver function, bleeding ulcers and intestinal permeability, the latter two described as “common,” as per the 2001 Physicians’ Desk Reference (PDR).
Pure Essentials Ultra Bone Repair uniquely and naturally supplies the full-range of joint-building blocks, thereby enhancing joint tissue repair and renewal. Its targeted nutrient combination also promotes quick pain relief, so that results are felt in days (rather than weeks or months).
The ingredients in Pure Essentials Ultra Bone Repair employ the active, fully soluble forms of glucosamine KCl, glucosamine sulfate, and chondroitin sulfate, plus collagen-building flavanols and molybdenum that are in few other products. Each of these active agents is shown to help people with sports injuries and osteoarthritis move pain-free and with greater joint flexibility. By itself each nutrient is effective, but together they synergistically build and restore function at the cellular level.
- Glucosamines are building blocks of glycosaminoglycans (GAG) and proteoglycans (PG). These naturally occurring chemicals in the body constitute the shock-absorbing, water-binding structure of cartilage. Sulfate activates glucosamine’s therapeutic effect. Unlike NSAIDS, which block proteoglycans synthesis, glucosamine and its sulfate address the causes of osteoarthritis. This halts and reverses cartilage degeneration and supplies the biochemical tools to rebuild damaged cartilage. According to a randomized, placebo-controlled Belgian study appearing in The Lancet in 2001, glucosamine sulfate actually reduces OA of the knee. The 212 study participants, all diagnosed with OA, receiving either 1,500 mg of glucosamine sulfate a day or placebo, were scanned at the beginning of the trial and again at one and three years. After three years, both OA and related symptoms became worse in the placebo group. No progression of OA was found after treatment in the glucosamine sulfate group and patients experienced improvement in their symptoms. Researchers concluded that glucosamine sulfate is useful as a long-term disease-modifying agent in OA.3.
Important to note is a comment by Dr. Jean-Yves Reginster of the University of Liege that study findings cannot be extrapolated to other over-the-counter products where the amount of active glucosamine is unknown. Additionally, glucosamine sulfate also out-performed NSAIDS in studies comparing their impact on joint function. Head-to-head against ibuprofen, after two weeks of treatment, GS not only showed more improvement of symptoms but also was significantly better tolerated.
- Chondroitin sulfate (CS) is another soluble joint-supportive, repair molecule. It works synergistically with glucosaminoglycans to rebuild cartilage. It has repair-promoting and anti-inflammatory properties, which ease pain, help heal wounds and has been shown to be protective against heart disease. In studies on its anti-inflammatory effects, patients who took CS moved joints more freely and without pain or the complications of NSAIDS.
Additional nutrients in the formulation supply additional benefits, such as:
- Oligomeric proanthocyanidins (OPC) flavanols that are soluble and solvent-free, reinforce collagen formation, and promote joint health
- Molybdenum, a mineral that aids in cartilage repair and further assissts joint repair by clearing the body of sulfitic and related toxic metabolites that interfere with repair and contribute to pain and fatigue
Better results are additionally due to purer ingredients and lack of contaminants, such as fillers, binders, or excipients that interfere with uptake or action in the body.
Pure Essentials Ultra Bone Repair is available in bottles of 90 or 180 capsules. For relief of osteoarthritis, sports injuries to joints, and chronic inflammatory joint pain, take three (3) capsules twice daily until comfort is fully restored then three (3) capsules daily for maintenance, or as directed by your health professional.
Three (3) Pure Essentials Ultra Bone Repair capsules provide:
Energized joint repair nutritives
Glucosamine sulfate HCl 900 mg
Glucosamine KCl 300 mg
Chondroitin sulfate (active, soluble) 225 mg
OPC 85+TM (proanthocyanidins) 45 mg
Molybdenum (as glycinate) 52 mcg
Magnesium (as C16 and C18 alkyls) † 6 mg
Vegetable fiber (organic croscarmellose) 367 mg
Kosher gelatin capsules 351 mg
†From whole, untreated palm fruit and leaf
Oliverieri U., et al. Drugs in Experimental and Clinical Research. 1991;17(1): 45.
“Osteoarthritis”: American College of Rheumatology. http://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Osteoarthritis#sthash.3STv6OK1.dpuf. Accessed 31 Aug 2016.
Qiu GX, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung. 1998; 48:469-474.
Reginster JY, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomized placebo-controlled clinical trial. Lancet. 2001;27:251-6.