Ultra B-12


Increase your energy.

Pure Essentials Ultra B-12 delivers the nutrient in its superior, activated form (hydroxocobalamin), which provides longer-lived and more effective B-12 action in the body. Its lozenge form further allows for maximum uptake and optimal delivery to the brain; individuals notice that they feel better more quickly, with studies showing nearly the same B-12 uptake from the lozenge as from injection.

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  • Benefits
  • Nutrients
  • Dosage
  • References


Maintaining SAMe (S-adenosyl methionine) in its beneficial form. SAMe is critical for the manufacture of neurotransmitters, as well as for detoxification.

• Promotion of heart health. Pure Essentials Ultra B-12, when taken with the synergistic nutrients B-6 and folic acid (both found in Pure Essentials 2), delivers maximum action for keeping homocysteine levels low. Homocysteine is an amino acid that is increasingly being correlated with cardiovascular risk. The correlation between homocysteine and vitamin B-12 is significant; nearly 57% of men with elevated homocysteine have low levels of B-12.

• Reactivation of folate. Vitamin B-12 reactivates folate, such that, if an individual has low levels of B-12, severe folic acid deficiency may develop. Similarly, a B-12-deficient individual taking only folic acid can make a B-12 deficiency worse (chronically low levels of B-12 result in megaloblastic anemia). It is thereby important to take both B-12 and folate, which can be found in Pure Essentials 2.

• Fighting fatigue. Hectic lifestyles, stress, and increasing environmental toxins can lead to exhaustion. Fortunately, B-12 stimulates the body’s utilization of proteins, fats, and carbohydrates, which increase energy. Research shows that 2,000 to 20,000 mcg daily are required for optimal energy. Additionally, elevated homocysteine levels are implicated in more than heart disease, and including fatigue. In a study of women with both chronic fatigue and fibromyalgia, researchers discovered that all of the patients had high levels of homocysteine in their cerebrospinal fluid. They also noted a significant correlation between high homocysteine levels and fatigue. The study emphasized the importance of the relationship between B-12 and homocysteine, showing that B-12 deficiency was a contributing factor. By decreasing levels of homocysteine in the central nervous system, B-12 can thereby help prevent and treat fatigue.



As a dietary supplement, take one (1) sublingual lozenge daily, or as directed by your health professional. Place lozenge under tongue and let dissolve.


Andres E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004 Aug;171(3):251-9.

Abalan F, et al. Incidence of vitamin B-12 and folic acid in patients admitted to a geriatric psychiatry unit. [Article in French] Encephale. 1984;10:9-12.

Glueck CJ, et al. Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients. Am J Cardiol. 1995 Jan 15;75:132-136.

Nilsson K, Gustafson L, Hultberg B: Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamines and folates in a psychogeriatric population. Dement Geriatr Cogn Disord. 1999 Nov-Dec;10(6):467-482.

Regland B, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;

ingredient Highlights


Although it is more expensive and difficult to obtain, hydroxocobalamin lasts longer and raises B-12 blood concentrations higher than other forms of vitamin B-12. It also requires no intrinsic factor for absorption and is taken-up directly by mucous membranes regardless of digestive competence. Thereafter, hydroxocobalamin is easily converted to active and short-lived methylcobalamin and adenosylcobalamin forms, as needed in the body. For these reasons, it is the only form Pure Essentials Ultra B-12 uses.

Vitamin B-12 has several important roles in the body, from maintaining the health of your nervous system to developing blood cells, supporting your adrenal glands and helping synthesize genetic material (e.g. DNA). And yet, we are hard-pressed to receive an adequate supply of this vital nutrient for a few reasons: most of our B-12 intake comes from food, yet today’s food supply is estimated to contain 78% less of it than in the 1960s. In addition, stress—which may reduce hydrochloric acid (HCl) and intrinsic factor production in the stomach—frequently impairs the nutrient’s absorption. Plus, the most commonly used forms of B-12 require activation in the body, making uptake less than 50%.