Dehydroepiandrosterone (DHEA) is a steroid hormone secreted primarily by the adrenal glands and, to a lesser extent, by the testes and ovaries. DHEA and its sulfate are the most abundant steroid hormones in the human body and can be found in blood, saliva, urine and cerebrospinal fluid. DHEA serves as a “buffer” reservoir of DHEA to be used for the intracellular synthesis of various estrogens and androgens throughout the human body. DHEA production peaks during the second decade of life. Beginning in the early 30s, DHEA levels typically decline by 10% per decade. In addition to the normal decline associated with aging, other possible causes of a decline in DHEA production include inflammation, blood sugar imbalances, as well as long-term stress.
DHEA functions as the counterpart to the stress hormone cortisol. Maintaining healthy DHEA levels is crucial for balancing the catabolic effects of cortisol. Each capsule provides 5 mg of DHEA derived from the wild yam, allowing for incremental oral supplementation and flexibility with numerous hormone balancing and stress-fighting protocols.
1 capsule per day or as recommended by your health care professional
• Bone Health - DHEA has been examined in numerous studies for its role in supporting bone health. In a double-blind, placebo-controlled study using 50mg/day, DHEA supplementation improved bone turnover and decreased osteoclast activity in women older than 70 years.
• Inflammatory balance - DHEA has been shown to maintain normal inflammatory balance by inhibiting the activation of nuclear factor-kβ and the secretion of inflammatory compounds such as IL-6 and IL-2.
• Hormonal Balance - DHEA is a precursor to estrogen and testosterone. In addition, DHEA may also have physiological actions unrelated to its function as a hormone precursor, as DHEA receptors are also present in human muscle cells.
|DHEA (Dehydroepiandrosterone)||5 mg|
2. Wolkowitz OM, Reus VI, Roberts E, et al. Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry 1997;41:311-318.
3. Genazzani AR, Stomati M, Bernardi F, et al. Dehydroepiandrosterone as neurosteroid: neuroendocrine effects in post-menopausal women. J Endocrinol Invest 1999;22 (suppl 10):19-23.
4. Rabkin JG, McElhiney MC, Rabkin R, McGrath PJ, Ferrando SJ. Placebo-controlled trial of dehydroepiandrosterone (DHEA) for treatment of nonmajor depression in patients with HIV/AIDS. Am J Psychiatry 2006;163(1):59-66.
5. Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Prov Natl Acad Sce USA 2000;97:4279-4284.
6. Von Muhlen D, Laughlin GA, Kritz-Silverstein D, et al. Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers and body composition in older adults: the DAWN trial. Osteoporos Int 2008;19:699-707.
7. Tok EC, Ertunc D, Oz U, et al. The effect of circulating androgens on bone mineral density in postmenopausal women. Maturitas 2004;48;235-242.
8. Straub RH, Konecna L, Hrach S, et al. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interlukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab 1998;83:2012-2017.
9. Andus T, Kleb F, Rogler G, et al. Patients with refractory Crohn’s disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study. Aliment Pharmacol Ther 2003;17:409-414.
10. Ravaglia G, Forti P, Maioli F, et al. The relationship of dehydroepiandrosterone sulfate (DHEA) to endocrinemetabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninetyyear-olds. J Clin Endocrinol Metab 1996; 81:1173-1178.
11. Genazzani AD, Stomati M, Bernardi F, et al. Long-term low-dose dehydroepiandrosterone and oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroids. Fertil Steril 2003;80:1495- 1501.