N-Acetyl Cysteine - N-acetyl cysteine (NAC) is a powerful amino acid that dissolves mucus by breaking up disulfide bonds which make up the protein network that contributes to mucus density. This results in improved drainage out of the sinus cavity. In a double-blind study examining 12 healthy volunteers with slow mucociliary clearance, NAC administration for 60 days resulted in a 35% increase in mucociliary clearance rate in treated subjects, compared to no improvement in the placebo group. Additional studies have also demonstrated an improvement in mucus clearance following NAC administration. Turmeric Root (Complete Turmeric Matrix) - Whole-root turmeric and its active compounds have been used in traditional Ayurvedic Medicine for centuries. New research on turmeric shows that more than curcumin, additional turmeric bioactives in turmeric have added benefits and enhance bioavailability. Sinatrol offers a full spectrum turmeric ingredient with an exclusive blend of bioactive turmeric nutrients. The complete turmeric matrix formula provides a comprehensive systemic effect where it maintains normal inflammatory balance, supports microbiome diversity and balances immune function.

Bromelain - Bromelain is a plant enzyme that is naturally found in the stem and fruit of the pineapple plant. Bromelain exerts a synergistic effect when combined with NAC due to its proteolytic (protein-digesting) effects. Bromelain has been shown to be effective at thinning nasal secretions and provides an additional benefit of balancing inflammatory response.

Berberine Sulfate Hydrate - Berberine sulfate is a botanical extract found in the roots and barks of various plants including Oregon grape root, barberry and goldenseal. Berberine extract has been shown to support immune response by increasing blood flow to the spleen and by activating immune compounds such as macrophages. Berberine maintains healthy sinus function by quieting localized inflammatory response- Berberine has been shown to inhibit activator protein 1 (AP-1) and inhibits thromboxane A2 from platelets.

Licorice Root Extract - Licorice root has been used in Western and Eastern cultures for thousands of years. Licorice’s health-promoting benefits include soothing respiratory irritation. The active components in licorice, glycyrrhizin and glycyrrhetinic acid, strengthen immune response by inducing interferon activity, activating macrophages and augmenting natural killer cell activity. Glycyrrhizin exerts its inflammatory balancing response by inhibiting the production of reacted oxygen species released by neutrophils.

Andrographis - Andrographis paniculata is a plant that has been used in Asian medicine for centuries. The immune boosting properties of andrographis have been research extensively in clinical studies- Per the analysis of seven double-blind controlled trials, andrographis has been shown to be a safe botanical for supporting upper respiratory tract health.

Eleuthero - Recent studies utilizing the combination of Eleuthero and Andrographis have demonstrated the combination of herbs to be particularly helpful for patients with upper respiratory challenges.

Thyme - Thyme has been traditionally used to help soothe sinuses and loosen phlegm. Thymol, the active ingredient in thyme, also has immune supporting properties and competes with pathogens commonly found throughout the sinuses and respiratory tract. The German Commission E has approved thyme to help support respiratory challenges.